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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9833

Title: Diamond-based DNA sensors: surface functionalization and read-out strategies
Authors: WENMACKERS, Sylvia
VERMEEREN, Veronique
VAN DE VEN, Martin
AMELOOT, Marcel
BIJNENS, Nathalie
HAENEN, Ken
MICHIELS, Luc
WAGNER, Patrick
Issue Date: 2009
Publisher: WILEY-V C H VERLAG GMBH, PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY
Citation: PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 206(3). p. 391-408
Abstract: This article reviews the Current state-of-the art of diamond-based DNA sensors. Some general concepts involved in biosensors are introduced and applied to DNA sensors. The properties of chemically vapor deposited (CVD) diamond relevant for this application are summed up, with special attention for the stability and bio-compatibility of the material. Several routes to functionalize the diamond Surface are considered. The physical properties of the obtained DNA layers are discussed in terms of surface density and molecular conformation. Possible read-out strategies are evaluated, including optical and electronic sensing. With diamond-based DNA sensors, real-time and label-free sensing is achieved.
Notes: Feature Article
URI: http://hdl.handle.net/1942/9833
DOI: 10.1002/pssa.200880486
ISI #: 000264691800002
ISSN: 1862-6300
Category: A1
Type: Journal Contribution
Validation: ecoom, 2010
Appears in Collections: Research publications

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