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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/8319

Title: Visualisation of the kinetics of macrophage infiltration during experimental autoimmune encephalomyelitis by magnetic resonance imaging
Authors: BAETEN, Kurt
HENDRIKS, Jerome
HELLINGS, Niels
THEUNISSEN, Evi
VANDERLOCHT, Joris
DE RYCK, Leen
GELAN, Jan
STINISSEN, Piet
ADRIAENSENS, Peter
Issue Date: 2008
Publisher: ELSEVIER SCIENCE BV
Citation: JOURNAL OF NEUROIMMUNOLOGY, 195(1-2). p. 1-6
Abstract: Macrophages are considered to be the predominant effector cells in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Ultra small particles of iron oxide (USPIO) can be used to detect macrophage infiltrates in the CNS with magnetic resonance imaging (MRI). Here, we investigated whether the kinetics of lesion formation in EAE can be visualised by altering the time point of USPIO injection and the time interval between particle injection and MRI. When USPIO are systemically injected 24 h before MRI, hypo intense regions are detected in different brain regions depending on the disease stage. These regions Correspond to sites of macrophage infiltration. A more complete visualisation of sites of inflammation is accomplished by USPIO injection at disease onset and postponing MRI to top of disease. This study demonstrates that the distribution pattern and amount of inflammatory lesions detected with USPIO, depends on timing of USPIO administration and subsequent MRI. These findings are important for a correct application and interpretation of USPIO dependent contrast imaging of CNS inflammation. (C) 2007 Elsevier B.V. All rights reserved.
Notes: Hasselt Univ, Dept SBG, Inst Mat Res, IMO,Chem Div, B-3590 Diepenbeek, Belgium. Transnatl Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/8319
DOI: 10.1016/j.jneuroim.2007.11.008
ISI #: 000255802000001
ISSN: 0165-5728
Category: A1
Type: Journal Contribution
Validation: ecoom, 2009
Appears in Collections: Research Institute: Centre for Environmental Sciences
Institute for Materials Research
Biomedical Research Institute
Immunology - Biochemistry
Morphology
Organic and Bio-polymer Chemistry
Applied and Analytical Chemistry
Materials Physics

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