Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/28231

Title: Air pollution and telomere length in adults: A systematic review and meta-analysis of observational studies
Authors: Miri, Mohammad
Nazarzadeh, Milad
Alahabadi, Ahmad
Ehrampoush, Mohammad Hassan
Rad, Abolfazi
Lotfi, Mohammad Hassan
Sheikhha, Mohammad Hassan
Sakhvidi, Mohammad Javad Zare
Nawrot, Tim S.
Dadvand, Payam
Issue Date: 2019
Citation: ENVIRONMENTAL POLLUTION, 244, p. 636-647
Abstract: Telomere length (TL) has been suggested to be a surrogate for cellular ageing, and a record of cumulative inflammation and oxidative stress over life. An emerging body of evidence has associated exposure to air pollution to changes in TL. To date there is no available systematic review of literature on this association. We aimed to systematically review and conduct meta-analysis of published studies on the relationship between air pollution and TL in adults. Electronic databases were systematically searched for available English language studies on the association between air pollution and TL published up to 1 July 2018. Meta-analyses were conducted following MOOSE guidelines. The heterogeneity in the reported associations was assessed using Cochran's Q test and quantified as I-2 index. Publication bias was assessed using Egger's regression. Our search identified 19 eligible studies including 11 retrospective and eight prospective studies of which, four had excellent quality, ten had good quality and five had fair quality. Meta analysis result of two studies on long-term exposure to PM2.5 showed an inverse association between these exposures and it (for 5 mu g/m(3) PM2.5-0.03 95% CI; -0.05, -0.01). Meta-analysis of short-term exposure to PM2.5 with three studies and Polychlorinated Biphenyls (PCBs) with two studies revealed a direct association between these exposures and TL, (0.03 95% CI; 0.02, 0.04 and 0.10 95% CI; 0.06, 0.15 respectively). No statistically significant relationship between exposure to PM10 and polycyclic aromatic hydrocarbons (PAHs) exposure and it were observed. We observed suggestive evidence for associations between air pollution and TL with potentially different direction of associations for short- and long-term exposures. (C) 2018 Published by Elsevier Ltd.
Notes: [Miri, Mohammad; Alahabadi, Ahmad] Sabzevar Univ Med Sci, Sch Publ Hlth, Dept Environm Hlth, Cellular & Mol Res Ctr, Sabzevar, Iran. [Nazarzadeh, Milad] Univ Oxford, George Inst Global Hlth, Oxford, England. [Nazarzadeh, Milad] Torbat Heydariyeh Univ Med Sci, Collaborat Ctr Meta Anal Res ccMETA, Torbat Heydariyeh, Iran. [Ehrampoush, Mohammad Hassan] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Environm Hlth, Environm Sci & Technol Res Ctr, Yazd, Iran. [Rad, Abolfazi] Sabzevar Univ Med Sci, Cellular & Mol Res Ctr, Sabzevar, Iran. [Lotfi, Mohammad Hassan] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Yazd, Iran. [Sheikhha, Mohammad Hassan] Shahid Sadoughi Univ Med Sci, Yazd Reprod Sci Inst, Res & Clin Ctr Infertil, Yazd, Iran. [Sakhvidi, Mohammad Javad Zare] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Occupat Hlth, Occupat Hlth Res Ctr, Yazd, Iran. [Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium. [Nawrot, Tim S.] Leuven Univ, Dept Publ Hlth & Primary Care, Leuven, Belgium. [Dadvand, Payam] ISGlobal, Doctor Aiguader 88, Barcelona 08003, Spain. [Dadvand, Payam] Pompeu Fabra Univ, Barcelona, Catalonia, Spain. [Dadvand, Payam] Ciber Epidemiol & Publ Hlth CIBERESP, Madrid, Spain.
URI: http://hdl.handle.net/1942/28231
DOI: 10.1016/j.envpol.2018.09.130
ISI #: 000452940700068
ISSN: 0269-7491
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
Published version1.82 MBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.