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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/14383

Title: The effect of histamine, a traumatic brain injury mediator, on the function of aquaporin-4 in rat brain in vivo
Authors: Smets, A.
Nuydens, R.
De Jongh, R.
Pintelon, I.
Thys, S.
Timmermans, J. P.
Rigo, J. M.
Meert, T.
Issue Date: 2009
Publisher: MEDIMOND S R L
Citation: Baron, A; Chneiweiss, H (Ed.). 9TH EUROPEAN MEETING ON GLIAL CELLS IN HEALTH AND DISEASE, p. 153-156
Abstract: The high levels of histamine in brain after traumatic brain injury and the observed influence of histamine on aquaporin-1 (AQP-1) localization in gastric cells, lead to the hypothesis that histamine could play a major role in the pathophysiology of brain edema An intracerebroventricular (ICV) histamine induced brain edema model was developed in rats. Infusion of concentrations >= 50 mM histamine resulted in a dose-dependent intracranial pressure (ICP) increase and death. Furthermore, histological experiments showed the internalization of membrane-expressed AQP4 after histamine challenge. The decreased fraction of functional membrane-associated AQP4 might result in an increased intracranial p[ressure. In this new experimental rat mode, the functional activity of novel treatment options for increased ICP, IV or ICV administration, can readily be tested.
Notes: Address: Smets, A (reprint author), Univ Hasselt, Biomed Res Unit BIOMED, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/14383
ISI #: 000292191900030
ISBN: 978-88-7587-521-3
Category: C1
Type: Proceedings Paper
Validation: ecoom, 2012
Appears in Collections: Biomedical Research Institute
Immunology - Biochemistry
Physiology

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