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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/13615

Title: Glutathione Is a Key Player in Metal-Induced Oxidative Stress Defenses
Authors: Jozefczak, Marijke
Remans, Tony
Vangronsveld, Jaco
Cuypers, Ann
Issue Date: 2012
Publisher: MDPI AG
Citation: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 132 (3), p. 3145-3175
Abstract: Since the industrial revolution, the production, and consequently the emission of metals, has increased exponentially, overwhelming the natural cycles of metals in many ecosystems. Metals display a diverse array of physico-chemical properties such as essential versus non-essential and redox-active versus non-redox-active. In general, all metals can lead to toxicity and oxidative stress when taken up in excessive amounts, imposing a serious threat to the environment and human health. In order to cope with different kinds of metals, plants possess defense strategies in which glutathione (GSH; gamma-glu-cys-gly) plays a central role as chelating agent, antioxidant and signaling component. Therefore, this review highlights the role of GSH in: (1) metal homeostasis; (2) antioxidative defense; and (3) signal transduction under metal stress. The diverse functions of GSH originate from the sulfhydryl group in cysteine, enabling GSH to chelate metals and participate in redox cycling.
Notes: [Jozefczak, Marijke; Remans, Tony; Vangronsveld, Jaco; Cuypers, Ann] Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/13615
DOI: 10.3390/ijms13033145
ISI #: 000302174500038
ISSN: 1422-0067
Category: A1
Type: Journal Contribution
Validation: ecoom, 2013
Appears in Collections: Environmental Biology
Research Institute: Centre for Environmental Sciences

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