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Immunology - Biochemistry : [1258]

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Neuro-inflammatory and autoimmune disease We study the disease mechanism of multiple sclerosis and rheumatoid arthritis, two autoimmune diseases that target the central nervous system and joints respectively. We are particularly interested in the underlying immune dysfunctions (e.g. T cell regulation defects) in these diseases, and try to unravel the molecular and cellular events involved in tissue destruction and tissue repair. We are using various in vitro approaches (lymphocyte and neuronal cell cultures) and in vivo animal models (rodents) to study these research questions. We are also developing new therapeutic strategies for these diseases (e.g. T cell vaccination). In addition we use proteomics and phage display technologies to identify and test new disease markers. We are specialized in brain and cerebrospinal fluid proteomics. Molecular markers are further tested for their application in diagnosis, prognosis or theranostics. Biosensors Together with the Institute for Materials Research of our university, we are developing new biosensors to measure disease related molecules. We use conjugated polymers and CVD diamond for the development of new biolectronic devices using specific antibodies or oligonucleotide probes.

Neuro-inflammatory and autoimmune disease We study the disease mechanism of multiple sclerosis and rheumatoid arthritis, two autoimmune diseases that target the central nervous system and joints respectively. We are particularly interested in the underlying immune dysfunctions (e.g. T cell regulation defects) in these diseases, and try to unravel the molecular and cellular events involved in tissue destruction and tissue repair. We are using various in vitro approaches (lymphocyte and neuronal cell cultures) and in vivo animal models (rodents) to study these research questions. We are also developing new therapeutic strategies for these diseases (e.g. T cell vaccination). In addition we use proteomics and phage display technologies to identify and test new disease markers. We are specialized in brain and cerebrospinal fluid proteomics. Molecular markers are further tested for their application in diagnosis, prognosis or theranostics. Biosensors Together with the Institute for Materials Research of our university, we are developing new biosensors to measure disease related molecules. We use conjugated polymers and CVD diamond for the development of new biolectronic devices using specific antibodies or oligonucleotide probes.

Recent Submissions

Study of CD4+CD25+FOXP3+ regulatory T cells in patients with multiple sclerosis

Study of T-cell parameters in Rheumatoid Arthritis

Role of Natural Killer T cells in Rheumatoid Arthritis

Intention tremor in multiple sclerosis during visual and proprioceptive movement control

The role of immunosenescence and CD4+CD28null T cells in autoimmune disease

 

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